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Higher CSF/serum fr...
Higher CSF/serum free-T4 ratio is associated with improvement of quality of life during treatment with L-thyroxine
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- Funkquist, Anders, 1977- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Neurology, Halland County Hospital, Halmstad, Sweden,Halland Cty Hosp, Dept Med, Neurol, Halmstad, Sweden.;Örebro Univ, Sch Med Sci, Örebro, Sweden.
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- Wandt, B. (author)
- Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Örebro Univ, Örebro Univ Hosp, Örebro, Sweden.;Örebro Univ, Sch Hlth & Med Sci, Örebro, Sweden.
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Mölndal, Sweden.
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China,Univ Gothenburg, Sahlgrenska Acad, Mölndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Gothenburg, Sweden.;UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, London, England.;UK Dementia Res Inst UCL, London, England.;Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China.
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- Svensson, Johan, 1964 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.
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- Bjellerup, P. (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Cent Hosp Vastmanland, Dept Lab Med, Västerås, Sweden.
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- Freund-Levi, Yvonne, 1956- (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Örebro Univ Hosp, Dept Geriatr, Örebro, Sweden.;Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England.
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- Sjoberg, S. (author)
- Karolinska Institutet,Sophiahemmet Högskola,Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.;Halland Cty Hosp, Dept Med, Endocrinol, Halmstad, Sweden.;Sophiahemmet Univ, Dept Hlth Promot Sci, Stockholm, Sweden.
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(creator_code:org_t)
- Wiley-Blackwell Publishing Inc. 2023
- 2023
- English.
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In: Journal of Neuroendocrinology. - : Wiley-Blackwell Publishing Inc.. - 0953-8194 .- 1365-2826. ; 35:5
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Abstract
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- Up to 20% of individuals with primary hypothyroidism treated with L-thyroxine still suffer from severe symptoms. These are supposedly brain derived and involve both cognitive and emotional domains. Previously, no consistent relationship has been found between thyroid hormones (TH) or TSH levels in blood and quality of life (QoL). Recently, we reported an association between cerebrospinal fluid (CSF)/serum free-thyroxine (f-T4) ratio and QoL, in juvenile hypothyroid patients. Here, we investigated if CSF/serum f-T4 ratio and QoL estimates correlate also during L-thyroxine treatment. Moreover, the CSF biomarker neurogranin (Ng) was used as a biomarker for synaptic function and integrity in clinical research. Ng is partially controlled by TH and therefore we investigated the relationship between QoL parameters and Ng levels. Patients diagnosed with primary hypothyroidism were investigated using vital parameters, serum and CSF analyses of TH, TSH, Ng and QoL questionnaires. Similar procedures were performed after 6 months of treatment. The most marked associations with QoL were found for CSF/serum f-T4 ratio, which was strongly related to several QoL parameters such as the mental subscore of SF-36 (r = 0.83, p < .0005). Ng, which did not differ from that in our healthy controls, was lower in some patients during treatment and higher in others. However, the change in Ng during treatment was significantly correlated with QoL parameters including the mental subscore of SF-36 (r = -0.86, p < .0001). In addition, the CSF/serum f-T4 ratio correlated with the change in Ng (r = -0.75, p = .001). Our results suggest that the ratio between CSF and serum f-T4 is an important biomarker for QoL during treatment of patients with primary hypothyroidism, so far in research, but in the future maybe also in clinical settings. Moreover, this ratio also correlates with the changes in Ng levels during L-thyroxine treatment, further supporting the impact of the TH balance between serum and CSF on QoL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- cerebrospinal fluid biomarkers
- cognition
- neurogranin
- primary
- hypothyroidism
- quality of life
- thyrotropin-releasing-hormone
- thyroid-hormone
- cerebrospinal-fluid
- brain-development
- hypothyroidism
- transporters
- modulation
- depression
- neurons
- scale
- Endocrinology & Metabolism
- Neurosciences & Neurology
- Cerebrospinal fluid biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Funkquist, Ander ...
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Wandt, B.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Svensson, Johan, ...
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Bjellerup, P.
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show more...
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Freund-Levi, Yvo ...
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Sjoberg, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg
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Örebro University
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Sophiahemmet University College
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Karolinska Institutet
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Uppsala University